background:
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1.
Function:
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
Subunit:
Interacts with YWHAB (By similarity).
Subcellular Location:
Nucleus
Tissue Specificity:
Widely expressed with the highest expression in peripheral blood leukocytes
Similarity:
Belongs to the akirin family.
Database links:
Entrez Gene: 55122 Human
Entrez Gene: 433693 Mouse
Entrez Gene: 297968 Rat
Omim: 615165 Human
SwissProt: Q53H80 Human
SwissProt: B1AXD8 Mouse
SwissProt: Q25C79 Rat
Unigene: 485915 Human
Unigene: 389532 Mouse
Unigene: 399624 Mouse
Unigene: 3858 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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