Rabbit Anti-AKIRIN1/FITC Conjugated antibody

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AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN.

Cat:

SL9081R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human AKIRIN1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

22kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.

Similarity:
Belongs to the akirin family.

Database links:

Entrez Gene: 79647 Human

Entrez Gene: 13650 Mouse

Entrez Gene: 595134 Rat

Omim: 615164 Human

SwissProt: Q9H9L7 Human

SwissProt: Q99LF1 Mouse

Unigene: 293563 Human

Unigene: 27903 Mouse

Unigene: 390996 Mouse

Unigene: 486258 Mouse

Unigene: 3674 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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