Rabbit Anti-Macrophage mannose receptor 1/FITC Conjugated antibody

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Mannose Receptor; Macrophage mannose receptor 1; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor 1; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; OTTHUMP000

Cat:

SL4727R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human MRC1/CD206

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

160kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq].

Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Subcellular Location:
Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Similarity:
Contains 8 SLCtype lectin domains.
Contains 1 fibronectin type-II domain.
[SIMILARITY] Contains 1 ricin B-type lectin domain.

Database links:

Entrez Gene: 472 Human

Entrez Gene: 17533 Mouse

Entrez Gene: 291327 Rat

Omim: 153618 Human

SwissProt: P22897 Human

SwissProt: Q61830 Mouse

Unigene: 75182 Human

Unigene: 2019 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

巨噬细胞甘露糖受体,主要存在于巨噬细胞膜表面的模式识别受体，能够特异性识别甘露糖、岩藻糖或N-乙酰葡糖胺，介导巨噬细胞吞噬抗原，启动免疫反应.

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