background:
The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multi-protein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. HSPB2 (heat shock 27 kDa protein 2), also known as HSP 27 or MKBP, is a 182 amino acid protein that belongs to the heat shock protein family and is expressed preferentially in heart and skeletal muscle. Localized to mitochondria, HSPB2 functions as an ATP-dependent chaperone protein that plays a role in the refolding of denatured proteins and may also interact with the Actin cytoskeleton and prevent apoptotic cell death. HSPB2 is abundantly expressed in several cancer cell lines, suggesting that HSPB2 may be an important factor in tumor transformation and metastasis.
Function:
May regulate the kinase DMPK.
Subunit:
Interacts with DMPK; may enhance its kinase activity.
Subcellular Location:
Cytoplasm. Nucleus. Localizes to nuclear foci.
Tissue Specificity:
Expressed preferentially in skeletal muscle and heart.
Similarity:
Belongs to the small heat shock protein (HSP20) family.
Database links:
Entrez Gene: 508671 Cow
Entrez Gene: 611362 Dog
Entrez Gene: 100736126 Guinea pig
Entrez Gene: 101828097 Hamster
Entrez Gene: 3316 Human
Entrez Gene: 69253 Mouse
Entrez Gene: 100520143 Pig
Entrez Gene: 161476 Rat
Omim: 602179 Human
SwissProt: Q16082 Human
SwissProt: Q99PR8 Mouse
SwissProt: O35878 Rat
Unigene: 709660 Human
Unigene: 396 Mouse
Unigene: 22486 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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