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Rabbit Anti-HN1/FITC Conjugated antibody
background:
Hematological and neurological expressed 1 protein (HN1) is a 154 amino acid member of the HN1 family. HN1 has been proposed to play a role in embryo development, specifically hemopoietic cell and neurological development. Localized to the nucleus, HN1 is expressed in many fetal and adult tissues, with highest levels of expression in brain, colon, prostate, testis, thymus, skeletal muscle, peripheral blood cells and placenta. HN1 has been identified to have processed pseudogenes in the mouse, rat and human genomes, suggesting that HN1 and its pseudogenes represent a novel gene family. Three isoforms of HN1 exist as a result of alternative splicing events. HN1L (hematological and neurological expressed 1-like protein), also known as C16orf34 or L11, is a 190 amino acid protein that belongs to the HN1 family. Localizing to the cytoplasm as well as the nucleus, HN1L is expressed in liver, kidney, prostate, testis and uterus. HN1L gets upregulated in certain carcinomas, including squamous cell carcinoma (SCC), adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC) and bronchioalveolar carcinoma (BAC), and is also expressed in breast and uterine tumors. HN1L, along with HN1, may be involved in embryo development.
Subcellular Location:
Nucleus
Tissue Specificity:
Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
Post-translational modifications:
Isoform 3 initiator methionine is either acetylated or removed. In the latter case, the new N-terminal amino acid is then N-acetylated.
Similarity:
Belongs to the HN1 family.
Database links:
Entrez Gene: 51155 Human
Entrez Gene: 15374 Mouse
Entrez Gene: 287828 Rat
SwissProt: Q9UK76 Human
SwissProt: P97825 Mouse
SwissProt: Q6AXU6 Rat
Unigene: 532803 Human
Unigene: 1775 Mouse
Unigene: 198910 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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