Rabbit Anti-PDZK3/FITC Conjugated antibody

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Activated in prostate cancer protein; AIPC; KIAA0300; Likely ortholog of rat plakophilin related armadillo repeat protein interacting PDZ protein antibody PAPIN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain

Cat:

SL9037R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human PDZK3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

310kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Proteins containing PDZ domains have been shown frequently to bind the SLCtermini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. PDZK3 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, the PDZK3 gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.

Subunit:
Interacts with SCN10A, CTNND2 and PKP4 (By similarity).

Subcellular Location:
Cytoplasmic, Endoplasmic reticulum, Nuclear and Secreted

Tissue Specificity:
Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.

Post-translational modifications:
A secreted form is produced by caspase-mediated proteolytic cleavage (By similarity).

Similarity:
Contains 6 PDZ (DHR) domains.

Database links:

Entrez Gene: 23037 Human

Entrez Gene: 13670 Mouse

Entrez Gene: 65034 Rat

Omim: 610697 Human

SwissProt: O15018 Human

SwissProt: Q9QZR8 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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