background:
Pyridoxal kinase belongs to the pyridoxine kinase family and phosphorylates vitamin B6, a step necessary for the conversion of vitamin B6 to pyridoxal 5’ phosphate (PLP), the active form of vitamin B6. PLP acts as a coenzyme and functions to maintain homeostasis. Pyridoxal kinase is a 312-amino acid cytoplasmic protein that may act as a homodimer and is expressed ubiquitously. There are three known isoforms of pyridoxal kinase, and isoform 3 expression is observed in adult testis and spermatozoa. The optimum pH for pyridoxal kinase is between 5.5 and 6.0. PDXK, the gene that encodes the pyridoxal kinase protein, maps to chromosome 21q22.3 and may be a candidate gene for autoimmune polyglandular disease type 1, a genetic disorder that has been mapped to the same region on chromosome 21.
Function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Subunit:
Homodimer (Probable).
Subcellular Location:
Cytoplasm
Tissue Specificity:
Ubiquitous. Isoform 3 is detected in adult testis and spermatozoa.
Similarity:
Belongs to the pyridoxine kinase family.
Database links:
Entrez Gene: 8566 Human
Entrez Gene: 216134 Mouse
Omim: 179020 Human
SwissProt: O00764 Human
SwissProt: Q8K183 Mouse
Unigene: 284491 Human
Unigene: 206159 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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