background:
SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.
Function:
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Subunit:
Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
Similarity:
Contains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain.
Database links:
Entrez Gene: 23098 Human
Entrez Gene: 237868 Mouse
Omim: 607732 Human
SwissProt: Q6SZW1 Human
SwissProt: Q6PDS3 Mouse
Unigene: 446689 Human
Unigene: 743510 Human
Unigene: 210332 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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