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Rabbit Anti-TRPM1/FITC Conjugated antibody
background:
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Involvement in disease:
Defects in TRPM1 are the cause of congenital stationary night blindness type 1C (CSNB1C) [MIM:613216]. A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Function:
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Subcellular Location:
Cell membrane
Tissue Specificity:
Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.
DISEASE:
Defects in TRPM1 are the cause of congenital stationary night blindness type 1C (CSNB1C) [MIM:613216]. A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily.
Database links:
Entrez Gene: 4308 Human
Entrez Gene: 17364 Mouse
Entrez Gene: 361586 Rat
Omim: 603576 Human
SwissProt: O75560 Human
SwissProt: Q7Z4N2 Human
SwissProt: Q2TV84 Mouse
SwissProt: Q2WEA4 Rat
SwissProt: Q2WEA5 Rat
Unigene: 155942 Human
Unigene: 38875 Mouse
Unigene: 211311 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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