background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Function:
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Subunit:
Interacts with GRASP (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed in different regions of the adult brain as well as in fetal brain.
Similarity:
Belongs to the G-protein coupled receptor 3 family.
Database links:
Entrez Gene: 2912 Human
Entrez Gene: 108068 Mouse
Entrez Gene: 24415 Rat
Omim: 604099 Human
SwissProt: Q14416 Human
SwissProt: Q14BI2 Mouse
SwissProt: P31421 Rat
Unigene: 121510 Human
Unigene: 410822 Mouse
Unigene: 424639 Mouse
Unigene: 9681 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酸受体-代谢能2；主要参与细胞信号转导及突触传递，在G蛋白偶联受体蛋白信号转导途径中有一定的作用，并且有负调控腺苷酸环化酶的作用，为膜性蛋白，在胞膜、胞浆中表达。
|
|
