background:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CRY1 and CRY2.
Subcellular Location:
Nucleus. Cytoplasm. Predominantly nuclear.
Tissue Specificity:
Widely expressed.
Similarity:
Contains 1 F-box domain.
Contains 7 LRR (leucine-rich) repeats.
Database links:
UniProtKB/Swiss-Prot: Q9UKT7.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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