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Rabbit Anti-MX2 + MX1/FITC Conjugated antibody
background:
Members of the Dynamin family include GTPase, microtubule-associated proteins that are involved in cellular trafficking, including microtubule bundling and endocytosis. Mx1, also known as MxA, an interferon (IFN)-induced protein, acquires a high degree of resistance to influenza A virus and the rhabdo-virus vesicular stomatitis virus (VSV), which suggests that Mx1 plays an active role against influenza virus and the rhabdovirus VSV. Mx1 is a cytoplasmic protein that is 63% identical to the Mx2 protein, which lacks antiviral activity. Mx2 is also known as MxB and is localized at the cytoplasmic face of nuclear pores. Mx2 expression is not interferon-dependent and this protein is thought to regulate the efficiency and/or kinetics of nuclear import, a function which may have been usurped by its antiviral relatives.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the dynamin family.
Contains 1 GED domain.
Database links:
Entrez Gene: 4599 Human
Entrez Gene: 920 Human
Omim: 147150 Human
Omim: 147890 Human
Unigene: 517307 Human
Unigene: 926 Human
SwissProt: P20592 Human
SwissProt: P20591 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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