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Rabbit Anti-D4S234E/FITC Conjugated antibody
background:
NEEP21, also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).
Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein (Potential).
Similarity:
Belongs to the NSG family.
Database links:
Entrez Gene: 27065 Human
Entrez Gene: 18196 Mouse
Entrez Gene: 25247 Rat
Omim: 607645 Human
SwissProt: P42857 Human
SwissProt: Q62092 Mouse
SwissProt: P02683 Rat
Unigene: 518595 Human
Unigene: 7414 Mouse
Unigene: 2865 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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