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Rabbit Anti-FOXN1/FITC Conjugated antibody
background:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008].
Function:
Transcriptional regulator involved in development.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in thymus.
Similarity:
Contains 1 fork-head DNA-binding domain.
Database links:
Entrez Gene: 8456 Human
Omim: 600838 Human
SwissProt: O15353 Human
Unigene: 663679 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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