background:
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011].
Function:
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Subunit:
Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
Subcellular Location:
Membrane; Single-pass type I membrane protein. Isoform 7: Secreted.
Tissue Specificity:
Expressed in breast, placenta, kidney, liver and pancreas.
Similarity:
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Contains 2 fibronectin type-III domains.
Database links:
Entrez Gene: 100053793 Horse
Entrez Gene: 5618 Human
Entrez Gene: 414916 Pig
Entrez Gene: 24684 Rat
Omim: 176761 Human
SwissProt: P16471 Human
SwissProt: Q6JTA8 Pig
SwissProt: P14787 Rabbit
SwissProt: P05710 Rat
SwissProt: O46561 Sheep
Unigene: 368587 Human
Unigene: 9757 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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