background:
BTNL8 is a 500 amino acid single-pass type I membrane protein that belongs to the immunoglobulin superfamily and contains one B30.2/SPRY domain and one Ig-like SLVtype (immunoglobulin-like) domain. Expressed as multiple alternatively spliced isoforms, BTNL8 is encoded by a gene which maps to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 comprises about 6% of human genomic DNA. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm on chromosome 5 is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Subcellular Location:
Membrane; Single pass type I membrane protein
Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 B30.2/SPRY domain.
Contains 2 Ig-like SLVtype (immunoglobulin-like) domains.
Database links:
UniProtKB/Swiss-Prot: Q6UX41.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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