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Rabbit Anti-BTNL2/FITC Conjugated antibody
background:
Butyrophilin is a glycoprotein that is specifically expressed on the apical surface of mammary epithelial cells during lactation and becomes incorporated as an integral protein into the membrane of the milk fat globule during the budding and secretion of fat droplets into milk. BTNL2 (butyrophilin-like protein 2), also known as BTL-II, is a 455 amino acid single-pass type II membrane protein that acts as a negative regulator of T cell proliferation. Expressed in thymus, brain, kidney, heart, liver, small intestine, testis, ovary, pancreas and leukocytes, BTNL2 exists as at least six alternatively spliced isoforms, which are encoded by a gene located on human chromosome 6. Expression of BTNL2 isoform 3 is associated with susceptibility to sarcoidosis type 2 (SS2), an immune disorder that causes chronic inflammatory granulomatous lesions.
Function:
Negative regulator of T-cell proliferation.
Subcellular Location:
Membrane; Single-pass type II membrane.protein. Note=Isoform 2 is present in the nuclear, vesicle and.plasma membranes, isoform 3 is found in cytoplasmic vesicle.structures and is not membrane bound.
Tissue Specificity:
Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus..
DISEASE:
Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.
Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 3 Ig-like SLVtype (immunoglobulin-like) domains.
Database links:
Entrez Gene: 56244 Human
Omim: 606000 Human
SwissProt: Q9UIR0 Human
Unigene: 534471 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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