background:
BOLA1 (BolA-like protein 1), also known as CGI-143, is a member of the BolA/yrbA family of proteins. Members of this family are homologs of the Escherichia coli protein, BolA. BolA-like proteins are evolutionarily conserved from prokaryotes to eukaryotes and are believed to play a role in cell-cycle regulation or cell proliferation possibly via some sort of transcription regulation of other genes. In addition, BolA-like proteins may contain nucleic-acid binding properties, as is suggested by a fold structure that is similar to the KH-fold, a motif known to participate in nucleic-acid binding. Characteristic of BolA-like proteins which typically consist of approximately 100 amino acids, BOLA1 is a 137 amino acid protein.
Subcellular Location:
Secreted. Could be secreted via a non-classical export pathway.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the bolA/yrbA family.
Database links:
UniProtKB/Swiss-Prot: Q9Y3E2.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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