Function:
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.
Subunit:
Monomer. Interacts with LRPPRC. May interact with BCL2L1. An interaction with BCL2L1 was observed using a peptide, but not with the full-length protein. The full-length protein would have to undergo a major conformation change for the interaction to occur.
Subcellular Location:
Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion.
Tissue Specificity:
Detected in placenta.
Similarity:
Belongs to the HEBP family.
Database links:
UniProtKB/Swiss-Prot: Q9Y5Z4.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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