background:
The cadherins are a family of Ca++-dependent adhesion molecules that influence cell-cell binding and are critical to the maintenance of tissue structure and morphogenesis. OB-cadherin (osteoblast-cadherin, cadherin-11, OSF-4) has two forms, OB-cadherin-1 and OB-cadherin-2. OB-cadherin-2 has a truncated cytoplasmic domain, missing amino acids 694-796. Both OB-cadherins are expressed in osteoblastic cell lines with low expression seen in lungs, testis and brain.
Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subunit:
Interacts with PCDH8 (By similarity).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
DISEASE:
Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Similarity:
Contains 5 cadherin domains.
Database links:
Entrez Gene: 415797 Chicken
Entrez Gene: 785475 Cow
Entrez Gene: 1009 Human
Entrez Gene: 12552 Mouse
Entrez Gene: 8887 Rat
Omim: 600023 Human
SwissProt: O93319 Chicken
SwissProt: P55287 Human
SwissProt: P55288 Mouse
Unigene: 116471 Human
Unigene: 1571 Mouse
Unigene: 8900 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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