background:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Similarity:
Belongs to the synuclein family.
Database links:
Entrez Gene: 6620 Human
Entrez Gene: 104069 Mouse
Entrez Gene: 22893 Rat
Omim: 602569 Human
SwissProt: Q16143 Human
SwissProt: Q91ZZ3 Mouse
SwissProt: Q63754 Rat
Unigene: 90297 Human
Unigene: 200843 Mouse
Unigene: 20352 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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