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Rabbit Anti-UBE2E1/FITC Conjugated antibody
background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub SLCterminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2E1 and UBE2L3, also designated UBCH6 and UBCH7 respectively in human, are E2 conjugating enzymes that interact with various proteins. Specifically, UBE2E1 interacts with the tumor suppressor protein TSSC5. UBE2L3 has been shown to mediate c-fos degradation, NF-kB maturation, human papilloma virus-mediated p53 and Myc protein degradation.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.
Subunit:
Interacts with RNF14.
Subcellular Location:
Nucleus.
Post-translational modifications:
ISGylation suppresses ubiquitin E2 enzyme activity.
Similarity:
Belongs to the ubiquitin-conjugating enzyme family.
Database links:
Entrez Gene: 7324 Human
Entrez Gene: 22194 Mouse
Omim: 602916 Human
SwissProt: P51965 Human
SwissProt: P52482 Mouse
SwissProt: Q541Z5 Mouse
Unigene: 164853 Human
Unigene: 4429 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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