background:
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Function:
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors).
Subcellular Location:
Nucleus.
Tissue Specificity:
Heart.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Database links:
Entrez Gene: 9464 Human
Entrez Gene: 15111 Mouse
Entrez Gene: 64637 Rat
Entrez Gene: 58150 Zebrafish
Omim: 60487 Human
SwissProt: Q90690 Chicken
SwissProt: P61296 Human
SwissProt: Q61039 Mouse
SwissProt: P61295 Rat
SwissProt: P57102 Zebrafish
Unigene: 388245 Human
Unigene: 261588 Mouse
Unigene: 430844 Mouse
Unigene: 36496 Rat
Unigene: 41057 Rat
Unigene: 81423 Zebrafish
Unigene: 8328 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
