background:
Appears to be a potent inhibitor of regeneration following spinal cord injury.Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NIMP (NOGO-interacting mitochondrial protein), also known as RTN4IP1 (Reticulon-4-interacting protein 1), is a 396 amino acid mitochondrial protein that contains a SLCterminal oxidoreductaselike domain and numerous sites for phosphorylation. NIMP is expressed in mitochondrial-rich tissue such as kidney, heart, skeletal muscle and specific regions within the nervous system. Through interaction with Nogo, it is likely that NIMP plays a role in Nogo-induced inhibition of neurite growth. There are three isoforms of NIMP that are produced as a result of alternative splicing events.
Function:
Appears to be a potent inhibitor of regeneration following spinal cord injury.
Subunit:
Interacts with RTN4, UQCRC1 and UQCRC2 (By similarity).
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Database links:
Entrez Gene: 506626 Cow
Entrez Gene: 84816 Human
Entrez Gene: 170728 Mouse
Entrez Gene: 309912 Rat
Omim: 610502 Human
SwissProt: Q0VC50 Cow
SwissProt: Q8WWV3 Human
SwissProt: Q924D0 Mouse
Unigene: 155839 Human
Unigene: 390253 Mouse
Unigene: 220185 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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