background:
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.
Function:
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
Similarity:
Contains 1 cytochrome b561 domain.
Database links:
UniProtKB/Swiss-Prot: Q53TN4.1
Entrez Gene: 79901 Human
Entrez Gene: 73649 Mouse
Entrez Gene: 295669 Rat
Omim: 605745 Human
SwissProt: Q53TN4 Human
SwissProt: Q925G2 Mouse
SwissProt: Q5RKJ2 Rat
Unigene: 726027 Human
Unigene: 741213 Human
Unigene: 45435 Mouse
Unigene: 203500 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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