background:
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPRP2 (dipeptidyl-peptidase ISLVrelated protein 2), also known as DPP9 (dipeptidyl-peptidase 9), or DP9, is a member of the peptidase S9B family of proteins that exhibit prolyl oligopeptidase activity. DPRP2 localizes to the cytoplasm and is ubiquitously expressed with predominant expression in heart, muscle and liver. DPRP2 may play an important role in the regulation of signaling by peptide hormones.
Function:
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
Subcellular Location:
Cytoplasm, cytosol.
Tissue Specificity:
Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.
Similarity:
Belongs to the peptidase S9B family. DPPIV subfamily.
Database links:
UniProtKB/Swiss-Prot: Q86TI2.3
Entrez Gene: 91039 Human
Entrez Gene: 224897 Mouse
Entrez Gene: 301130 Rat
Omim: 608258 Human
SwissProt: Q86TI2 Human
SwissProt: Q8BVG4 Mouse
Unigene: 515081 Human
Unigene: 205535 Mouse
Unigene: 41201 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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