background:
The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.
Subunit:
Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Database links:
Entrez Gene: 56896 Human
Entrez Gene: 65254 Mouse
Entrez Gene: 100910964 Rat
Entrez Gene: 65208 Rat
Omim: 608383 Human
SwissProt: Q9BPU6 Human
SwissProt: Q9EQF6 Mouse
SwissProt: Q9JHU0 Rat
Unigene: 299315 Human
Unigene: 27732 Mouse
Unigene: 44871 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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