Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport.
Subcellular Location:
Cytoplasm, cytoskeleton. Associated with actin filaments.
Similarity:
Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.
Database links:
UniProtKB/Swiss-Prot: Q9ULE3.4
Entrez Gene: 27147 Human
SwissProt: Q9ULE3 Human
Unigene: 6385 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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