background:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the SLCterminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Function:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the SLCterminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Subunit:
Monomer. Interacts with REST.
Subcellular Location:
Nucleus (By similarity).
Tissue Specificity:
Expression is restricted to non-neuronal tissues.
Similarity:
Contains 1 FCP1 homology domain.
Database links:
UniProtKB/Swiss-Prot: O15194.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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