background:
GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.
Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).
Subcellular Location:
Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome.
Tissue Specificity:
Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.
Similarity:
Belongs to the IAN GTP-binding protein family.
Database links:
UniProtKB/Swiss-Prot: Q96F15.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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