Function:
Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.
Subunit:
Interacts with human PVRL4; this interaction allows virus infection of the respiratory epithelium (By similarity). Interacts with human MCP/CD46 antigen and SLAMF1.
Subcellular Location:
Virion membrane; Single-pass type II membrane protein (Potential). Host cell membrane; Single-pass type II membrane protein (By similarity).
Similarity:
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. Non-sialidase subfamily.
Database links:
UniProtKB/Swiss-Prot: P08362.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
麻疹病毒血凝素蛋白(Hemagglutinin protein,H)是介导麻疹病毒吸附、侵入宿主细胞的关键分子,麻疹病毒H蛋白在细胞膜上的表达，以及被麻疹病毒感染的细胞和未感染细胞的直接接触能够引起其受体CD46的表达下调.
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