background:
FunctionF-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Function:
F-box-like protein involved in the recruitment of theubiquitin/19S proteasome complex to nuclear receptor-regulatedtranscription units. Plays an essential role in transcriptionactivation mediated by nuclear receptors. Probably acts as integralcomponent of corepressor complexes that mediates the recruitment ofthe 19S proteasome complex, leading to the subsequent proteasomaldegradation of transcription repressor complexes, thereby allowingcofactor exchange (By similarity).
Subunit:
Probable component of the N-Cor repressor complex andsome E3 ubiquitin ligase complex (By similarity).
Subcellular Location:
Nucleus (By similarity).
Tissue Specificity:
Fetal brain and prostate.
Similarity:
Belongs to the WD repeat EBI family.
Contains 1 F-box-like domain.
Contains 1 LisH domain.
Contains 8 WD repeats.
Database links:
UniProtKB/Swiss-Prot: Q9BQ87.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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