background:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Function:
Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. Required for anchoring centrosomal pericentrin in bothinterphase and mitosis, for spindle organization and centrosomeintegrity.
Subunit:
Central component of the nucleosome remodeling andhistone deacetylase (NuRD) repressive complex. Interacts withTRIM28 and SERBP1. Interacts (via its SLCterminal) with HABP4.Interacts with PCNT; the interaction regulates centrosomeintegrity.
Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton,centrosome. Note=Associates with centrosomes in interphase andmitosis.
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
[SIMILARITY] Contains 2 PHD-type zinc fingers.
Database links:
UniProtKB/Swiss-Prot: Q12873.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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