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Rabbit Anti-ICBP90/UHRF1/FITC Conjugated antibody
background:
Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
Tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
Function:
Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
Subunit:
Interacts with histones H3, H1 and H2B (By similarity). Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Binds methylated CpG containing oligonucleotides.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
Post-translational modifications:
Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.
Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
Similarity:
Contains 1 PHD-type zinc finger.
Contains 2 RING-type zinc fingers.
Contains 1 ubiquitin-like domain.
Contains 1 YDG domain.
Database links:
Entrez Gene: 29128 Human
Omim: 607990 Human
SwissProt: Q96T88 Human
Unigene: 108106 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
UHRF1是一种核蛋白,通过DNA解螺旋酶而识别甲基化位点,UHRF1与一些组蛋白的结合事件对于维持正确的表观遗传学控制具有非常重要的意义。
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