background:
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
Tissue specificity:
Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.
Function:
Transcription factor required for TBX21/T-bet-dependentmaturation of Th1 cells as well as maintenance of Th1-specific geneexpression. Involved in embryogenesis and hematopoiesis (Bysimilarity).
Subcellular Location:
Nucleus (Potential).
Tissue Specificity:
Low level in normal B and T-cells, high levelin activated lymphocytes and monocytes. Also found in thymus,tonsil, bone marrow, developing vessels, and fetal brain.
Similarity:
Belongs to the H2.0 homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
UniProtKB/Swiss-Prot: Q14774.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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