background:
Sarcosin contains 1 BTB (POZ) domain and is required for pseudopod elongation in transformed cells. Sarcosin mRNA is up-regulated by less than two folds in the heart in human patients with HCM.
Function:
Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subunit:
Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, pseudopodium. Cell projection, ruffle. Note=Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.
Post-translational modifications:
Ubiquitinated and probably targeted for proteasome-independent degradation.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 5 Kelch repeats.
Database links:
UniProtKB/Swiss-Prot: O60662.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
