background:
COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. The prototype of this family, MURR1/COMMD1, suppresses NFkB by affecting the association of NF-kappaB with chromatin. COMMD7 (COMM domain-containing protein 7) interacts with COMMD1 via its COMM domain. It also associates with the NF-kappa-B complex and suppresses its transcriptional activity.
Function:
Associates with the NF-kappa-B complex and suppresses its transcriptional activity.
Subunit:
Interacts (via COMM domain) with COMMD1 (via COMM domain).
Tissue Specificity:
Widely expressed with highest expression in lung.
Similarity:
Contains 1 COMM domain.
Database links:
UniProtKB/Swiss-Prot: Q86VX2.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|