background:
Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Tissue specificity:
Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
Function:
Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Subunit:
Monomer and homodimer. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1. Interacts directly with SOCS1 and CUL2. Interacts directly the N-terminal region of ATP7B. Interacts with CCS, CDKN2A, RELA and NFKBIB. Identified in a complex with NF-kappa-B. Interacts with CLU.
Tissue Specificity:
Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
Post-translational modifications:
Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation.
Similarity:
Contains 1 COMM domain.
Database links:
UniProtKB/Swiss-Prot: Q8N668.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
COMMD蛋白家族中最典型的成员.它是一个多效性因子,参与许多生理活动,包括铜代谢、钠运输、对核因子κB(NF-κB)及低氧诱导因子1(HIF-1)的调节等，COMMD广泛存在于多细胞生物中,最典型的特征是它们的羧基端存在一个高度保守而独特的结构—COMMD结构域,为蛋白质间的相互作用提供了关键界面.
目前研究COMMD蛋白家族有10个成员,即COMMD1～10.COMMD1是COMMD蛋白家族中最先被证实且研究最为深入的蛋白质,在不同物种中广泛表达,在人类的不同组织表达存在差异.
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