Rabbit Anti-ICMT/FITC Conjugated antibody

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CMT; HSTE14; Icmt; ICMT_HUMAN; Isoprenylcysteine carboxylmethyltransferase; MGC39955; MGC95322; MST098; MSTP098; pcCMT; PCMT; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; Protein-S-isoprenylcysteine O-met

Cat:

SL8019R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CMT/Icmt

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

32kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Catalyzes the post-translational methylation of isoprenylated SLCterminal cysteine residues. Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Function:
Catalyzes the post-translational methylation of isoprenylated SLCterminal cysteine residues.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Similarity:
Belongs to the isoprenylcysteine O-methyltransferase family.

Database links:

Entrez Gene: 23463 Human

Entrez Gene: 57295 Mouse

Entrez Gene: 170818 Rat

Omim: 605851 Human

SwissProt: O60725 Human

SwissProt: Q9EQK7 Mouse

SwissProt: Q9WVM4 Rat

Unigene: 515688 Human

Unigene: 277464 Mouse

Unigene: 48709 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Icmt酶是异戊烯途径中的一种关键酶，它能将甲基加到Ras上。这种甲基标签能使Ras到达细胞中的最终目的地，Icmt酶能发送不控制生长的信号，因此，Icmt蛋白在保持细胞中的致癌基因Ras的开启状态中起到重要作用。（Ras是细胞的一种正常的遗传成分，但是这种基因的突变能够致使它促进细胞的失控生长。而且，在一半的结肠癌和90％的胰腺癌中发生了Ras基因突变）。

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