background:
This gene encodes a protein with an N-terminal RCC1 domain and a SLCterminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the SLCterminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008].
Function:
May be involved in cell cycle regulation by chromatin remodeling.
Subcellular Location:
Nucleus (Potential).
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Contains 2 BTB (POZ) domains.
Contains 6 RCC1 repeats.
Database links:
UniProtKB/Swiss-Prot: Q8NDN9.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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