Rabbit Anti-phospho-CDK5(Tyr15)/FITC Conjugated antibody

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Cdk5 (phospho Y15); p-Cdk5(Y15); Cdk 5; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit; CDK5

Cat:

SL6411R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Chicken,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human CDK5 around the phosphorylation site of Tyr15

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

32kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CDK5 (Cyclin Dependent Kinase 5) is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression. CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.

Subcellular Location:
Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium. Cell projection, growth cone. Cell junction, synapse, postsynaptic cell membrane,postsynaptic density. Isoform 2: Nucleus.

Tissue Specificity:
Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 1020 Human

Entrez Gene: 12568 Mouse

Entrez Gene: 140908 Rat

Omim: 123831 Human

SwissProt: Q00535 Human

SwissProt: P49615 Mouse

SwissProt: Q03114 Rat

Unigene: 647078 Human

Unigene: 298798 Mouse

Unigene: 10749 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞周期素依赖性激酶-5属于小丝氨酸／苏氨酸周期素依赖性激酶家族成员，虽与其他成员序列具有同源性，但功能却完全不一样，即与细胞周期关系不大，却在中枢神经系统的发育和神经元正常功能的维持中发挥重要作用，并与一些退行性疾病及药物成瘾有密切联系。
CDK-5是神经系统中重要的蛋白激酶之一,周期素依赖性激酶5在神经系统发育过程中,可调节轴突生长、神经元分化及迁移.最近研究表明,周期素依赖性激酶5激酶活性失调与阿尔茨海默病的发病有关.

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