Home
>
Product
>
Antibody
>
Rabbit Anti-CHORDC1/FITC Conjugated antibody
background:
Human CHP1 and the C. elegans homolog Chp are CHORD domain-containing proteins that are largely related, and their corresponding genes are evolutionarily conserved among various eukaryotic organisms (1,2). The unique CHORD domain is characterized as 60 amino acids in length, and contains six highly conserved cysteine residues, two histidine residues and a distinct Zn2+-binding domain (3). CHP1 and the other metazoan orthologs have tandem CHORD domains that are located at both the N- and SLC termini (1,4). These proteins are implicated in germline development and embryogenesis as mutations affecting the CHORD domain of the nematode protein Chp result in semisterility and embryonic lethality (1,5).
Function:
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Subunit:
InteractswithHSP90AA1,ROCK1andROCK2.InteractswithHSP90AB1andPPP5C
Tissue Specificity:
Underexpressedinmanybreastandlungcancers.
Similarity:
Contains2CHORDdomains.
Contains1CSdomain.
Database links:
Entrez Gene: 26973 Human
Entrez Gene: 66917 Mouse
Entrez Gene: 315447 Rat
Omim: 604353 Human
SwissProt: Q9UHD1 Human
SwissProt: Q9D1P4 Mouse
SwissProt: D4A4T9 Rat
Unigene: 22857 Human
Unigene: 479183 Mouse
Unigene: 6136 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|