background:
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012].
Function:
May play a role in maintaining the integrity of the tectorial membrane.
Subunit:
Monomer. Homodimer. Tetramer. Interacts with TECTA.
Subcellular Location:
Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane (By similarity).
DISEASE:
Defects in CEACAM16 are the cause of deafness autosomal dominant type 4B (DFNA4B) [MIM:614614]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Similarity:
Belongs to the immunoglobulin superfamily. CEA family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
UniProtKB/Swiss-Prot: Q2WEN9.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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