background:
May play a negative role in growth factor receptor signaling pathways.
Function:
Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.
Subunit:
Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination.
Subcellular Location:
Cytoplasm. Cell projection. Note=Cytoplasmic before and after growth factor treatment.
Tissue Specificity:
Widely expressed (at protein level).
Post-translational modifications:
Phosphorylated on tyrosine residues in response to EGF and PDGF.
Similarity:
Contains 6 ANK repeats.
Contains 1 PID domain.
Contains 2 SAM (sterile alpha motif) domains.
Database links:
Entrez Gene: 23294 Human
Entrez Gene: 224650 Mouse
Entrez Gene: 309639 Rat
Omim: 608994 Human
SwissProt: Q92625 Human
SwissProt: P59672 Mouse
Unigene: 656492 Human
Unigene: 32556 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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