Rabbit Anti-ANKRD13A/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ANKRD13A/FITC Conjugated antibody

ANKRD13; ANKRD13A ankyrin repeat domain 13A; ANKRD13A; Ankyrin repeat domain 13; Protein KE03; AN13A_HUMAN.

Cat:

SL7963R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human ANKRD13A

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

68kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

Subunit:
Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.

Subcellular Location:
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.

Post-translational modifications:
Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.

Similarity:
Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats.

Database links:

Entrez Gene: 88455 Human

Entrez Gene: 68420 Mouse

SwissProt: Q8IZ07 Human

SwissProt: Q80UP5 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall