Home
>
Product
>
Antibody
>
Rabbit Anti-ANKRD13A/FITC Conjugated antibody
Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subunit:
Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.
Subcellular Location:
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Post-translational modifications:
Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.
Similarity:
Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats.
Database links:
Entrez Gene: 88455 Human
Entrez Gene: 68420 Mouse
SwissProt: Q8IZ07 Human
SwissProt: Q80UP5 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|