background:
The alpha/beta hydrolase superfamily comprise diverse members that are involved in important biochemical processes and related to various diseases. They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical alpha/beta hydrolase fold, which consists of an eightstranded parallel alpha/beta structure. They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile. Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer’s disease, obesity and blood clotting disorders. The Ab hydrolase domain containing (ASHD) gene subfamily is comprised of 15 mostly uncharacterized members. Most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow. ASHD1 plays a role in metabolizing smoking xenobiotics. ASHD2 participates in the development of atherosclerosis. ASHD4 is involved in an alternative synthesis pathway of NAE. Mutations in ASHD5 contribute to Chanarin-Dorfman syndrome. ABDH6 may play a role in nervous system metabolism and signaling. ASHD13 is a 337 amino acid single-pass membrane protein that belongs to the ASHD family.
Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).
Similarity:
Belongs to the serine esterase family.
Database links:
Entrez Gene: 84945 Human
Entrez Gene: 68904 Mouse
Entrez Gene: 306630 Rat
Entrez Gene: 561333 Zebrafish
SwissProt: Q7L211 Human
SwissProt: Q80UX8 Mouse
SwissProt: Q32LS6 Zebrafish
Unigene: 183528 Human
Unigene: 142570 Mouse
Unigene: 395885 Mouse
Unigene: 88157 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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