background:
Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to USLV or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.
Tissue specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cell junction, synapse. Note=Localizes to synaptic vesicles in neurons. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to USLV or MMS-induced DNA damage.
Tissue Specificity:
Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Contains 1 protein kinase domain.
Contains 1 UBA domain.
Database links:
Entrez Gene: 84446 Human
Entrez Gene: 381979 Mouse
Entrez Gene: 499073 Rat
Omim: 609235 Human
SwissProt: Q8TDC3 Human
SwissProt: Q5RJI5 Mouse
SwissProt: B2DD29 Rat
Unigene: 182081 Human
Unigene: 297064 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
