background:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Function:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Subunit:
Monomer and homodimer.
Subcellular Location:
Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
Similarity:
Contains 1 AH domain.
Contains 1 PDZ (DHR) domain.
Database links:
UniProtKB/Swiss-Prot: Q9NRD5.2
Entrez Gene: 9463 Human
Entrez Gene: 18693 Mouse
Entrez Gene: 84591 Rat
Omim: 605926 Human
SwissProt: Q9NRD5 Human
SwissProt: Q62083 Mouse
SwissProt: Q9EP80 Rat
Unigene: 36871 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PICK1是衔接PKCα和膜上众多受体的关键蛋白之一，是细胞质中的膜结合蛋白,在蛋白质转运,以及细胞内信号转导过程中发挥重要作用；而在男性不育方面，PICK1蛋白也是促进精子顶体发育的关键蛋白，缺失PICK1蛋白将导致精子受破坏，失去活动能力和受精能力。
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