background:
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the SLCterminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HISLV1 virus, interacts with HISLV1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HISLV1 mRNA splicing and promoting the production of the doubly spliced HISLV1 protein Nef.
Tissue specificity:Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
Function:
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the SLCterminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HISLV1 virus, interacts with HISLV1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HISLV1 mRNA splicing and promoting the production of the doubly spliced HISLV1 protein Nef.
Subunit:
Interacts with CCNL1 and CCNL2 (By similarity). Interacts with C1QBP. Interacts with HISLV1 Tat.
Subcellular Location:
Nucleus speckle.
Tissue Specificity:
Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.
Database links:
UniProtKB/Swiss-Prot: Q14004.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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