Rabbit Anti-MNAT1/FITC Conjugated antibody

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MNAT 1; CAP35; CDK activating kinase assembly factor MAT1; CDK7/cyclin H assembly factor; Cyclin G1 interacting protein; MAT1; Menage a trois; MNAT 1; p35; p36; RING finger protein 66; RING finger protein MAT1; RNF66; MAT1_HUMAN.

Cat:

SL7896R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human MNAT1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
MNAT1 (or 'menage a trois-1') is a subunit of the CAK complex which is a multisubunit protein that includes CDK7, cyclin H, as well as MNAT1. CAK (CDK-activating kinase) phosphorylates and thus activates CDKS (Cyclin-dependent kinases) which play an essential role in cell cycle control of eukaryotic cells.

Function:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive SLCterminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Subunit:
Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.

Similarity:
Contains 1 RING-type zinc finger.
Contains 1 UIM (ubiquitin-interacting motif) repeat.

Database links:

Entrez Gene: 4331 Human

Entrez Gene: 17420 Mouse

Entrez Gene: 266713 Rat

Omim: 602659 Human

SwissProt: P51948 Human

SwissProt: P51949 Mouse

Unigene: 509523 Human

Unigene: 246750 Mouse

Unigene: 15168 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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